Chanettee Wannasaen has maintained her two-shot lead in the LPGA Tour event in Ohio, with top-ranked fellow Thai star Jeeno Thitikul and Charley Hull making big moves.

Wannasaen, the 21-year-old trying to win for the third straight year on tour, shot a four-under 68 at soggy TPC River's Bend on Friday to reach 13-under 131. She opened with a 63.

"I just want me to play like this," Wannasaen said.

"I'm not thinking about the score. I just want hit my driver like this; hit irons like this. I just want to enjoy with the golf again."

Thitikul and Englishwoman Hull (65) were tied for second with Olivia Cowan (65) of Germany.

Minjee Lee is the leading Australian at eight-under after her 67, with Gabriela Ruffles (70) one shot back.

Grace Kim (69), Robyn Choi (67), Steph Kyriacou (70) and Hira Naveed (72) all made the weekend two-under cut, but Hannah Green missed out by one shot after her 68.

Wannasaen holed out for eagle on a par-4 for the second straight day, this time on the 13th - her fourth hole of of the day. She did it on No.10 in the first round.

The 22-year-old Thitikul had a 64, making four-straight birdies in a back-nine 30. She won in June at Liberty National for her fifth LPGA Tour victory.

Hull eagled the par-5 11th and birdied the final two holes for a 65. She is coming off a runner-up finish in Houston as part of the Ladies European Tour.

"I'm just firing at the pin, pretty much," Hull said.

"I like going at the pins. I find it boring otherwise."

Swede Maja Stark (66), South Korea's Sei Young Kim (68) and American Gigi Stoll (69) were 10-under.

Winless this season, second-ranked Nelly Korda (68) topped the group at nine-under after a 68.

"You just have to really stay aggressive," Korda said.

"The greens are pretty soft, so you can, but hitting fairways, hitting greens is the key to eventually having a putt."

Defending champion Lydia Ko of New Zealand shot 69 to get to five-under, but home favourite Alison Lee missed the cut in her first event since giving birth to a boy in April, shooting 76-73.