After capturing the third leg of women's golf's fabled slam with victory at last month's PGA Championship, Lee needs an Open triumph and a Chevron Championship to complete the set.
Americans Mickey Wright, Pat Bradley, Julie Inkster and Louise Suggs, South Korean Inbee Park, great Swede Annika Sorenstam and Australian Karrie Webb are the only players recognised with achieving a career grand slam after winning four different major championships.
But only the legendary Webb, Australia's most prolific major winner with seven all up, has completed the "super grand slam" of five different majors.
After some much-needed R&R and no golf in London, Lee admits trying to join her childhood idol and mentor is a huge goal.
"All the majors are a great motivator for me, so yes, I definitely want to win it (the British Open) at some stage and be able to get the career grand slam," the 29-year-old said.
"That would be absolutely amazing ... and now that I look back at it right now, this is what I can say: that's quite a big motivation for me to try and get over the line."
With a tie for third behind victorious compatriot Grace Kim at this month's Evian Championship, a joint 14th at the Chevron and an equal 22nd at the US Open, Lee also enters the week leading the ANNIKA Major Award.
With another strong finish in Wales, the 2022 recipient could join world No.1 Nelly Korda (2024) and Ariya Jutanugarn (2018) as only the third player to claim major-player-of-the-year honours twice.
To do so, Lee knows she will need to be on top of her game at the picturesque seaside layout hosting the Open for the first time.
"It's going to be a really great challenge," the West Australian said.
"You have to be really strong off the tees, with driver, whatever you have off the tee.
"And then the wind and the way the holes are shaped, it's kind of tricky.
"There's a lot of shots that go up into the air and the green's are a little bit lower, so you can't really see where they land. There's a couple of blind shots.
"So it reminds me of an in-between links and kind of a regular golf course, but without trees.
"The landscape is really lovely and you can see the ocean, so it just feels like it's going to be a great trip, just a good test."
With five top-10 finishes in 11 Open starts, Lee is the most credentialled of the nine Australians in the 145-strong field.
But any number of the classy contingent are capable of contending.
Lee is joined by fellow major champions Hannah Green and Kim, Gabriela Ruffels, who led into the final round of the Evian Championship, 2024 Evian runner-up Steph Kyriacou and fellow LPGA Tour stars Cassie Porter, Karis Davidson and Hira Naveed.
European Tour pro Kirsten Rudgeley will round out a nine-strong Australian challenge on her major championship debut.
The purse for golf's final major of the year is $US9.5 million ($A14.6 million), with the winner pocketing $US1.425 million ($A2.2 million).
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