Vu pocketed a record winner's cheque of $US1.35 million ($A2.08 million) after leaving English hope and fellow third-round leader Charley Hull trailing in her dust on Sunday.

The 25-year-old sank six birdies and posted only one bogey in a final round five-under-par 67 to finish firmly in control at the Walton Heath Golf Club in Surrey.

Finishing at 14-under for the tournament, Vu's victory comes after she won the Chevron Championship in May.

Now she is the first female player to win two majors in the same year since Jin Young Ko in 2019, and the first American woman since Juli Inkster in 1999.

From being outside the top-100 midway through 2022, her first year back on the LPGA Tour, Vu on Monday will become the fourth American to top the women's rankings since they was introduced in 2006.

"It sounds almost unreal," Vu said. "It just comes down to not thinking about winning, playing one shot at a time. This golf course really forces you to do that, it really tests you. That was my only goal.

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"I was not calm inside, trust me. Just to be here today, I can't thank my family enough for believing in me."

Heading into next month's Solheim Cup, what a year this has been for U.S players. Three of the five women's majors have been won by Americans – Allisen Corpuz also won the U.S Women’s Open title at Pebble Beach – and that's not happened since 2014.

Vu was barely given enough time to take in the moment amid applause before she was soaked in champagne by her friends, who promptly emptied the bottle over her head.

Hull had raised hopes of a first home winner since Georgia Hall's victory in 2018 when she signed for 68 on Saturday but an eagle on the 11th was not enough as she made four bogeys and just one birdie to finish with a final round of 73.

"It sounds almost unreal. It just comes down to not thinking about winning, playing one shot at a time. This golf course really forces you to do that, it really tests you. That was my only goal." - Lilia Vu.

Vu praised the Briton's performance, saying: "I love playing with Charley. She's so fun to watch. I remember even yesterday looking back at her crowd and really wanting to play with her today.

"She's so great, so nice and a really great golfer – you guys watch out for her!"

South Korea's Jiyai Shin was a further shot back in third, while her compatriots Kim Hyo-joo (74) and Amy Yang (70) shared fourth spot on six-under-par.

Grace Kim (73) was the leading Australian in a share of 36th spot at two-over, three strokes clear of Minjee Lee (77) in tie for 50th.

Dethroned World No.1 Nelly Korda (74) tied for 11th at two-under, with Frenchwoman Celine Boutier, who won the FREED GROUP Women's Scottish Open and Amundi Evian Championship in recent weeks, carding an bogey-free round of 68 to finish one stroke further back in equal 16th.